Middle East is a region that throughout the history has been facing difficulties in terms of a stable political structure. This complicated and problematic structure of Middle East leads to some drawbacks for Turkey as a country located on the conflux of the region in establishing and applying its foreign policy towards this terrain. Due to its certain features such as geographical proximity, historical, social and cultural links, and the energy resources there, Middle East has always preserved its importance in every epoch, as one of the essential issues of Turkish foreign policy. Therefore the crisis and the developments took place in Middle East certainly have direct or indirect effects, differentiating upon the period, on Turkish foreign policy. Since it is with profound importance to be accurately grasped, with a historical perspective, for the potent, intensity and the course of these effects in order to assess the existing policies and to develop new strategies if necessary. When the dynamic structure of the foreign policy took into account, it becomes crucial to analyse this region properly that sits on the center of several problems. In this study, by underlining the term Middle East, the policies of Turkey regarding the region have been investigated in a certain period of time and the effective factors for those policies have been sized up. The necessity has been harped on that in order to remain its national interests and geopolitical advantage, and to turn the crisis and developments in Middle East into benefits, Turkey should realize the regional drivings and its potential.